Platelet Activation and Platelet Indices as Markers for Disease Progression in Women with Breast Cancer

Background: Several studies reported the role platelet activation, volume (MPV) and other Indices in breast cancer but data is inconsistent and/or diverse. The aim of this study was to systematically evaluate activation indices women with BC as predictors for progression poor prognosis. Methods: Patients were recruited from our local oncology center between 2019 2020 following ethics approval. 80 patients locally invasive BC, 20 metastatic 100 controls recruited. ADP-induced assessed by light-transmission aggregometry. Platelet P-selectin (CD62P) expression without ADP stimulation flow cytometry. A comprehensive analysis count (PVIs) (MPV, PDW, MPV/P PDW/P) conducted. Data analyzed relation tumor pathology, hormone receptors (ER, PR, HER-2) proliferation index Ki-67. Regression analyses conducted prediction prognosis, aggression potential. Results: We found a significant increase aggregation (MA), CD62P expression, CD62P+ADP, MPV, PDW/P group compared group. Univariate regression showed significance ADP, MA, MPV PDW/P. Conclusion: can be used simple low-cost conclude specific help predict prognosis females BC.